{"id":3972234510408,"title":"Boston Heart Cholesterol Balance Test","handle":"boston-heart-cholesterol-balance-test","description":"\u003cp\u003e\u003cstrong\u003eAvailable in clinic and online. \u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eBoston Heart’s exclusive Cholesterol Balance test directly measures the major production markers (lathosterol and desmosterol) and absorption markers (beta-sitosterol, campesterol and cholestanol) for circulating plasma cholesterol. The levels of these markers are indicators of LDL-C lowering response to treatments (e.g., statins or ezetimibe). This information enables healthcare providers to prescribe the most effective treatment strategy to lower LDL-C and help patients achieve their LDL-C goal.\u003c\/p\u003e\n\n\u003ch4\u003ePreferred Specimen\u003c\/h4\u003e\n\n\u003cp\u003e1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)\u003c\/p\u003e\n\n\u003ch4\u003eAlternative Specimen\u003c\/h4\u003e\n\n\u003cp\u003e1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST\/Tiger Top)\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eSchedule your visit\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eTo know which diagnostic tests you need, schedule a \u003ca href=\"https:\/\/afhlife.com\/products\/discovery-visit-s0104\"\u003eDiscovery Visit\u003c\/a\u003e and talk with our doctors.\u003c\/p\u003e\n\n\u003cp\u003eTo learn more about your test results, schedule an \u003ca href=\"https:\/\/afhlife.com\/products\/insight-visit-s0105\"\u003eInsight Visit\u003c\/a\u003e and discuss with our doctors.\u003c\/p\u003e\n\n\u003cp\u003eTo convert your diagnostic test result to health actions, schedule an \u003ca href=\"https:\/\/afhlife.com\/products\/action-visit-s0106\"\u003eAction Visit\u003c\/a\u003e and get intelligent lifestyle design and recommendations from our doctors.\u003c\/p\u003e\n\n\u003cp\u003eTo monitor your health journey, schedule a \u003ca href=\"https:\/\/afhlife.com\/products\/monitoring-visit-s0107\"\u003eMonitoring Visit\u003c\/a\u003e to be fully supported on habitual and lifestyle changes.\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cp\u003ePlease contact us at (714) 864-3730 or pe@anti-fragilityhealth.com to order your test and for more information.\u003c\/p\u003e\n","published_at":"2019-07-29T14:09:18-07:00","created_at":"2019-07-29T14:09:18-07:00","vendor":"Boston Heart","type":"Test 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The levels of these markers are indicators of LDL-C lowering response to treatments (e.g., statins or ezetimibe). This information enables healthcare providers to prescribe the most effective treatment strategy to lower LDL-C and help patients achieve their LDL-C goal.\u003c\/p\u003e\n\n\u003ch4\u003ePreferred Specimen\u003c\/h4\u003e\n\n\u003cp\u003e1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)\u003c\/p\u003e\n\n\u003ch4\u003eAlternative Specimen\u003c\/h4\u003e\n\n\u003cp\u003e1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST\/Tiger Top)\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cp\u003e\u003cstrong\u003eSchedule your visit\u003c\/strong\u003e\u003c\/p\u003e\n\n\u003cp\u003eTo know which diagnostic tests you need, schedule a \u003ca href=\"https:\/\/afhlife.com\/products\/discovery-visit-s0104\"\u003eDiscovery Visit\u003c\/a\u003e and talk with our doctors.\u003c\/p\u003e\n\n\u003cp\u003eTo learn more about your test results, schedule an \u003ca href=\"https:\/\/afhlife.com\/products\/insight-visit-s0105\"\u003eInsight Visit\u003c\/a\u003e and discuss with our doctors.\u003c\/p\u003e\n\n\u003cp\u003eTo convert your diagnostic test result to health actions, schedule an \u003ca href=\"https:\/\/afhlife.com\/products\/action-visit-s0106\"\u003eAction Visit\u003c\/a\u003e and get intelligent lifestyle design and recommendations from our doctors.\u003c\/p\u003e\n\n\u003cp\u003eTo monitor your health journey, schedule a \u003ca href=\"https:\/\/afhlife.com\/products\/monitoring-visit-s0107\"\u003eMonitoring Visit\u003c\/a\u003e to be fully supported on habitual and lifestyle changes.\u003c\/p\u003e\n\n\u003cp\u003e \u003c\/p\u003e\n\n\u003cp\u003ePlease contact us at (714) 864-3730 or pe@anti-fragilityhealth.com to order your test and for more information.\u003c\/p\u003e\n"}

Boston Heart Cholesterol Balance Test

Price: Login to See the Price and Member Discount

$100.00

Available in clinic and online. 

Boston Heart’s exclusive Cholesterol Balance test directly measures the major production markers (lathosterol and desmosterol) and absorption markers (beta-sitosterol, campesterol and cholestanol) for circulating plasma cholesterol. The levels of these markers are indicators of LDL-C lowering response to treatments (e.g., statins or ezetimibe). This information enables healthcare providers to prescribe the most effective treatment strategy to lower LDL-C and help patients achieve their LDL-C goal.

Preferred Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Alternative Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

 

Schedule your visit

To know which diagnostic tests you need, schedule a Discovery Visit and talk with our doctors.

To learn more about your test results, schedule an Insight Visit and discuss with our doctors.

To convert your diagnostic test result to health actions, schedule an Action Visit and get intelligent lifestyle design and recommendations from our doctors.

To monitor your health journey, schedule a Monitoring Visit to be fully supported on habitual and lifestyle changes.

 

Please contact us at (714) 864-3730 or pe@anti-fragilityhealth.com to order your test and for more information.

Sku : A2771
Brand : Boston Heart

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Boston Heart Cholesterol Balance® Test

Abnormalities in cholesterol metabolism have been associated with patient response to statin and ezetimibe therapy for LDL cholesterol (LDL-C) lowering.

Boston Heart’s exclusive Cholesterol Balance test directly measures the major production markers (lathosterol and desmosterol) and absorption markers (beta-sitosterol, campesterol and cholestanol) for circulating plasma cholesterol. The levels of these markers are indicators of LDL-C lowering response to treatments (e.g., statins or ezetimibe). This information enables healthcare providers to prescribe the most effective treatment strategy to lower LDL-C and help patients achieve their LDL-C goal.

Test Details

Boston Heart Diagnostics Cholesterol Balance® test measures markers of cholesterol production (lathosterol and desmosterol) and absorption (beta-sitosterol, campesterol, and cholestanol)

Methodology

Lipid extraction followed by capillary column gas liquid chromatography and mass spectrometry (GC/MS)

Patient Preparation

8-12 hour fast prior to collection. Patient may drink water only.

Preferred Specimen

1.0 mL EDTA plasma (0.5 mL minimum) collected in plasma separator tube (Pearl Top)

Alternative Specimen

1.0 mL serum (0.5 mL minimum) collected in serum separator tube (SST/Tiger Top)

Transport Temperature

Refrigerated (ship on frozen cold packs)

Stability

Refrigerated: 5 days

 

Lab Values

Lathosterol

Marker of cholesterol production

  • Optimal: <85 μmol/mmol of total cholesterol (TC)
  • Borderline: 85-125 μmol/mmol of TC
  • High: >125 μmol/mmol of TC
  • Alert: >7.0 mg/L (absolute value)

Desmosterol

Marker of cholesterol production

  • Optimal: <65 μmol/mmol of TC
  • Borderline: 65-75 μmol/mmol of TC
  • High: >75 μmol/mmol of TC
  • Alert: >5.0 mg/L (absolute value)

Beta-sitosterol

Marker of cholesterol absorption

  • Optimal: <115 μmol/mmol of TC
  • Borderline: 115-155 μmol/mmol of TC
  • High: >155 μmol/mmol of TC
  • Alert: >7.0 mg/L (absolute value)

Campesterol

Marker of cholesterol absorption

  • Optimal: <170 μmol/mmol of TC
  • Borderline: 170-230 μmol/mmol of TC
  • High: >230 μmol/mmol of TC
  • Alert: >10.0 mg/L (absolute value)

Cholestanol

Marker of cholesterol absorption

  • Very high absolute value: >15.0 mg/L

Cholesterol Balance Score

Production/Absorption

  • Optimal: <0.5
  • Borderline: 0.5-1.1
  • High: >1.1

 

Clinical Significance

High lathosterol and desmosterol indicate cholesterol overproduction1

  • Associated with higher LDL-C and increased CVD risk
  • Associated with familial combined hyperlipidemia2

High campesterol and beta-sitosterol indicate cholesterol overabsorption

  • Associated with higher LDL-C and increased CVD risk
  • May be associated with tendon xanthomas, premature CVD and phytosterolemia if values are very high3

High absolute value of cholestanol indicates decreased conversion of cholesterol to the bile acid chenodeoxycholate4

  • May be associated with tendon xanthomas, neurologic disease and cerebrotendinous xanthomatosis if values are very high

References:

  1. Matthan NR, Resteghini N, Robertson M, et al. Cholesterol absorption and synthesis markers in individuals with and without a CHD event during pravastatin therapy: Insights from the PROSPER trial. J Lipid Res. 2010;51(1):202–209.
  2. Van Himbergen TM, Otokozawa S, Matthan NR, et al. Familial combined hyperlipidemia is associated with alterations in the cholesterol synthesis pathway. Arterioscler Thromb Vasc Biol. 2010;30(1):113–120.
  3. Patel MD, Thompson PD. Phytosterols and vascular disease. Atherosclerosis. 2006;186(1):12–19.
  4. Björkhem I, Leoni V, Meaney S. Genetic connections between neurological disorders and cholesterol metabolism. J Lipid Res. 2010;51(9):2489–2503.

 

Treatment Options

Initiate appropriate treatment after correcting contributing causes for elevated LDL-C

  • Lifestyle modification (if indicated)
  • Overproducer—Consider statin. If statin is indicated, or if dosage is being increased, consider testing patient for SLCO1B1 before prescribing
  • Overabsorber— Consider adding soluble fiber
  • Statin with ezetimibe may be used together for additional LDL-C lowering

Boston Heart Cholesterol Balance Test directly measures

  • The major production markers (lathosterol and desmosterol)
  • Absorption markers (beta-sitosterol, campesterol and cholestanol) for circulating plasma cholesterol

Methodology

Lipid extraction followed by capillary column gas liquid chromatography and mass spectrometry (GC/MS)

Patient Preparation

8-12 hour fast prior to collection. Patient may drink water only.

Instructions for Specimen Preparation and Handling